Brugia malayi: patterns of expression of surface-associated antigens.
Identifieur interne : 00D161 ( Main/Exploration ); précédent : 00D160; suivant : 00D162Brugia malayi: patterns of expression of surface-associated antigens.
Auteurs : N. Storey [États-Unis] ; M. PhilippSource :
- Experimental parasitology [ 0014-4894 ] ; 1992.
Descripteurs français
- KwdFr :
- Animaux, Antigènes d'helminthe (biosynthèse), Antigènes de surface (biosynthèse), Brugia (croissance et développement), Brugia (immunologie), Filariose lymphatique (parasitologie), Gerbillinae, Glycoprotéines (biosynthèse), Larve (immunologie), Masse moléculaire, Mâle, Protéines d'helminthes (biosynthèse), Tests aux précipitines, Électrophorèse sur gel de polyacrylamide.
- MESH :
- biosynthèse : Antigènes d'helminthe, Antigènes de surface, Glycoprotéines, Protéines d'helminthes.
- croissance et développement : Brugia.
- immunologie : Brugia, Larve.
- parasitologie : Filariose lymphatique.
- Animaux, Gerbillinae, Masse moléculaire, Mâle, Tests aux précipitines, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Animals, Antigens, Helminth (biosynthesis), Antigens, Surface (biosynthesis), Brugia (growth & development), Brugia (immunology), Electrophoresis, Polyacrylamide Gel, Elephantiasis, Filarial (parasitology), Gerbillinae, Glycoproteins (biosynthesis), Helminth Proteins (biosynthesis), Larva (immunology), Male, Molecular Weight, Precipitin Tests.
- MESH :
- chemical , biosynthesis : Antigens, Helminth, Antigens, Surface, Glycoproteins, Helminth Proteins.
- growth & development : Brugia.
- immunology : Brugia, Larva.
- parasitology : Elephantiasis, Filarial.
- Animals, Electrophoresis, Polyacrylamide Gel, Gerbillinae, Male, Molecular Weight, Precipitin Tests.
Abstract
Patterns of expression of surface-associated antigens were analyzed in the filarial nematode Brugia malayi immediately prior, and during development in the vertebrate host. Two surface-associated protein molecules, i.e., accessible to surface radioiodination and soluble in aqueous buffers, were investigated: Mrs 29-30,000 and 16,000, both of which are antigenic in infected animals. The Mr 29-30,000 glycoprotein is expressed in a surface-associated manner by adult worms and by fourth-stage larvae, but is not detectable in preparasitic third-stage larvae. The 16,000 component, which appears not to be glycosylated, is surface-associated in adult worms and fourth-stage larvae. In contrast to the 29-30,000 glycoprotein, the 16,000 protein is also expressed both by pre- and postparastic third-stage larvae. However, it becomes surface-associated only after infection. Thus, immediately prior, and during development within the vertebrate host, B. malayi displays at least two different patterns of expression of surface-associated antigens: (i) de novo, intiated either immediately after infection (phase specific) or during genesis of the fourth-stage larva (stage specific); (ii) continuous, but with phase-dependent surface exposure of previously cryptic antigens, during the transition from intermediate to definitive host.
PubMed: 1730272
Affiliations:
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Le document en format XML
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Storey</name><affiliation wicri:level="2"><nlm:affiliation>New England Biolabs, Inc., Beverly, Massachusetts 01915.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>New England Biolabs, Inc., Beverly</wicri:cityArea></affiliation></author><author><name sortKey="Philipp, M" sort="Philipp, M" uniqKey="Philipp M" first="M" last="Philipp">M. Philipp</name></author></analytic><series><title level="j">Experimental parasitology</title><idno type="ISSN">0014-4894</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Helminth (biosynthesis)</term><term>Antigens, Surface (biosynthesis)</term><term>Brugia (growth & development)</term><term>Brugia (immunology)</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Elephantiasis, Filarial (parasitology)</term><term>Gerbillinae</term><term>Glycoproteins (biosynthesis)</term><term>Helminth Proteins (biosynthesis)</term><term>Larva (immunology)</term><term>Male</term><term>Molecular Weight</term><term>Precipitin Tests</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes d'helminthe (biosynthèse)</term><term>Antigènes de surface (biosynthèse)</term><term>Brugia (croissance et développement)</term><term>Brugia (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Gerbillinae</term><term>Glycoprotéines (biosynthèse)</term><term>Larve (immunologie)</term><term>Masse moléculaire</term><term>Mâle</term><term>Protéines d'helminthes (biosynthèse)</term><term>Tests aux précipitines</term><term>Électrophorèse sur gel de polyacrylamide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antigens, Helminth</term><term>Antigens, Surface</term><term>Glycoproteins</term><term>Helminth Proteins</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Antigènes de surface</term><term>Glycoprotéines</term><term>Protéines d'helminthes</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Brugia</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Brugia</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia</term><term>Larve</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Larva</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Gerbillinae</term><term>Male</term><term>Molecular Weight</term><term>Precipitin Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Gerbillinae</term><term>Masse moléculaire</term><term>Mâle</term><term>Tests aux précipitines</term><term>Électrophorèse sur gel de polyacrylamide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patterns of expression of surface-associated antigens were analyzed in the filarial nematode Brugia malayi immediately prior, and during development in the vertebrate host. Two surface-associated protein molecules, i.e., accessible to surface radioiodination and soluble in aqueous buffers, were investigated: Mrs 29-30,000 and 16,000, both of which are antigenic in infected animals. The Mr 29-30,000 glycoprotein is expressed in a surface-associated manner by adult worms and by fourth-stage larvae, but is not detectable in preparasitic third-stage larvae. The 16,000 component, which appears not to be glycosylated, is surface-associated in adult worms and fourth-stage larvae. In contrast to the 29-30,000 glycoprotein, the 16,000 protein is also expressed both by pre- and postparastic third-stage larvae. However, it becomes surface-associated only after infection. Thus, immediately prior, and during development within the vertebrate host, B. malayi displays at least two different patterns of expression of surface-associated antigens: (i) de novo, intiated either immediately after infection (phase specific) or during genesis of the fourth-stage larva (stage specific); (ii) continuous, but with phase-dependent surface exposure of previously cryptic antigens, during the transition from intermediate to definitive host.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Philipp, M" sort="Philipp, M" uniqKey="Philipp M" first="M" last="Philipp">M. Philipp</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Storey, N" sort="Storey, N" uniqKey="Storey N" first="N" last="Storey">N. Storey</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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